Genotoxicity (OECD 471)

Mutagenicity / Genotoxicity tests Bacterial Back Mutation Test (Ames test) (ISO 10993-3, OECD 471)

Bacterial reverse-mutation test, Salmonella / microsome test system, also called Ames test, is one of the most widely used short-term bacterial test systems, which are most widely used in the investigation of the mutagenic effects of chemical substances, which are best standardized in terms of test parameters and whose validity is accepted with chemicals known to have mutagen-carcinogenic effects. is one. In this test system, 5 different proposed S. typhimurium mutant strains are used.

The AMES test is a test system based on the ability of histidine-dependent mutant Salmonella strains to reproduce in a histidine-free environment by back-mutating due to the effect of mutagenic substances.